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Product Catalogue
MPI
DEXATRONE
Scientific Name:
Dexamethasone
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COMPOSITION
Tablets : Each tablet contains 0.5 mg Dexamethasone USP
Elixir : Each 5 ml contains 0.5 mg Dexamethasone USP
PROPERTIES
Dexamethasone belongs to a class of drugs known as corticosteroids, it has an anti-inflammatory and anti-allergic action.
INDICATIONS
DEXATRONE is prescribed for a wide range of disorders including allergic conditions, rheumatic conditions, skin diseases, eye diseases, endocrine disorders, respiratory diseases, blood disorders and some others, especially for intensive treatment during shorter periods.
CONTRA INDICATIONS
Systemic fungal infections, administration of live virus vaccines. There is an enhanced effect of corticosteroids in patients with hypothyroidism and in those with cirrhosis
SIDE EFFECTS
Corticosteroids can cause a number of side effects which include fluid and electrolyte disturbances like salt and water retention.
Cardiovascular, musculo-skeletal, gastrointestinal, dermatological, endocrine, ophthalmic and metabolic effects and thromboembolism may occur.
Corticosteroids may activate latent amebiasis, and may mask or enhance infections.
Prolonged use may produce glaucoma with possible damage to optic nerves.
PRECAUTIONS
Use with caution in patients with the following :
A history of allergies to any drug, anaphylactic reactions have occurred, nonspecific ulcerative colitis, diverticulitis, recent intestinal anastomoses, peptic ulcers, renal insufficiency, hypertension, osteoporosis, infectious diseases, myasthenia gravis, ocular herpes simplex, psychotic tendencies and in prolonged therapy (especially in infants and children).
When corticosteroid therapy is prolonged, patients with previous tubercular infections should receive chemoprophylaxis.
DRUG INTERACTIONS
Use with caution in conjunction with acetylsalicylic acid and anticoagulants. Hypokalemia may occur, especially in patients receiving potassium –depleting diuretics.
Phenytoin, phenobarbital, ephedrine and rifampin may enhance the metabolic clearance of corticosteroids
PREGNANCY AND NURSING MOTHERS
Pregnant and nursing mothers should consult their physician.
WITHDRAWAL OF THE DRUG
Secondary adrenocortical insufficiency may result from the abrupt withdrawal of corticosteroids.
Dosage should be decreased or discontinued gradually after several days.
DOSAGE AND ADMINISTRATION
Depending on the conditions of the patient and the disease being treated: (0.5-15 mg/day).
Cerebral edema : 2 mg two or three times a day.
Adrenogenital syndrome: usually 0.5 - 1.5 mg/day.
In chronic conditions requiring long-term therapy, use the lowest dosage that provides adequate relief.
PACKING
Tablets : Pack of 20 tabs.
Elixir : Bottle of 60 ml.
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