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Product Catalogue
MPI
CARDIOSPIRIN SR
Scientific Name:
Acetylsalicylic acid
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COMPOSITION
Each tablet contains : Acetylsalicylic Acid 81 mg
PHARMACOLOGY AND INDICATIONS
Aspirin’s anti platelet and antithrombotic activity (inhibition of prostaglandins synthesis) has led to its use in numerous disorders provoked or caused by thrombosis, mainly the following:
- Secondary and primary prevention of myocardial infarction and stroke in patients with angina pectoris.
- Previous MI, atrial fibrillation, or transient ischaemic attacks ,and in the prevention of restenosis following coronary surgery .
- Prevention of pregnancy induced hypertension.
- Prevention of deep vein thrombosis following surgery.
DOSAGE &ADMINISTRATION
- Angina pectoris ,transient ischaemic attacks : 81 mg (1 tablet) daily .
- Atrial fibrillation,postcoronary surgery, prevention of restenosis: 325 mg (4tablets) daily .
- Myocardial infarction: 160-325 mg (2-4 tablets) daily .It has been shown that a daily dosage of 160 mg for one month after hospital admission for MI may significantly reduce the risk of death .
- It is important to fix the dosage by your physician.
CONTRAINDICATIONS
- Hemophilia, or other hemorrhagic disorders .
- Patients with gout.
- Lactation period, first and last 3 months of pregnancy (unless advised by the physician)
- Known aspirin induced allergies, urticaria and asthma.
PRECAUTIONS
-Use with care in patients with lesions of the gastric mucosa, renal or hepatic impairment.
-Aspirin increases bleeding time, decreases platelet adhesiveness and should be withdrawn prior to surgical procedures.
SIDE EFFECTS
- Gastrointestinal disturbances such as nausea, dyspepsia, vomiting, and rarely slight blood loss may occur.
- Aspirin may provoke allergies in patients at risk.
DRUG INTERACTIONS
- Alcohol enhances the side effects of the gastrointestinal tract.
- Co-administration with dipyridamole,metoclopramide,or metoprolol increases salicylate concentration in the plasma. Aspirin may increase the pharmacologic effects of coumarine-like anticoagulants, antidiabetics, phenytoin, methotrexate and valproic acid, and may decrease the uricosuric agents’(such as probencid and sulphynpyrazone) effect. Thus, co-administration with the above should be monitored only by the physician’s advice.
TREATMENT OF OVERDOSAGE
In acute salicylate overdosage, the stomach should be emptied by gastric lavage and remaining quantities may be adsorbed by activated charcoal, and known procedures of handling salicylate toxicity should be taken.
PACKING
50 tablets
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